Medical Research

Interpreting MAE research is difficult and confusing not only because of the medical jargon but also because the variety of investigators present us with conflicting definitions, statistics and findings. When reviewing this material it is important to take note of the submission date and appreciate that earlier research does not consider newer medication and better treatment options which have greatly improved outcomes for our children. Also, earlier definitions of MAE included children who would no longer be classified as MAE, for example, children who would nowadays be associated with Severe Myoclonic-Epilepsy of Infancy (SMEI) or Lennox-Gastaut syndrome (LGS) or Benign Myoclonic Epilepsy of Infancy (BMEI) which distorted prognosis/outcome findings. For this reason, earlier research is not truly representative.

Myoclonic Epilepsies - Advances in Neurology - Volume 95
Publisher : Lippincott Williams & Wilkins (available via and
Editors: Antonio Delgado Escueta, Renzo Guerrini, Marco T. Medina, Pierre Genton,
Michelle Bureau, Charlotte Dravet
Date of publish: 2005

Chapter 11 - Myoclonic-astatic epilepsy of early childhood - definition, course,
nosography, and genetics (including treatment table)

Neubauer BA, Hahn A, Doose H, et al

Chapter 12 - Idiopathic myoclonic-astatic epilepsy of early childhood
- nosology based on electrophysiologic and long-term follow-up study of patients

by Oguni H, et al

Try your local epilepsy organisation's library, or you can purchase it from Individual chapters can be purchased from

Delineation of cryptogenic Lennox-Gastaut syndrome and myoclonic astatic epilepsy using multiple correspondence analysis
by Kaminska A, Ickowicz A, Plouin P, Bru MF, Dellatolas G, Dulac O
Date of publish: 1999
Delineation of LGS & MAE by Kaminska A et al

Myoclonic-astatic epilepsy of childhood
by Fritz Dreifuss and Olivier Dulac
Date of submission: August 16, 1993
Date of update: October 2, 1998
Medline SEARCH DATE: September 17, 1998

Treatment and Long-term Prognosis of Myoclonic-Astatic Epilepsy of Early Childhood
by Hirokazu Oguni et al
Date of publish: Undated, based on patients recruited between 1968 and 1992
Treatment and Long-term Prognosis of MAE by Oguni et al

Myoclonic-astatic epilepsy of early childhood
by Herman Doose
Date of publish: 1992
Myoclonic-astatic epilepsy of early childhood by Herman Doose, 1992